BDBM50581523 CHEMBL5092943

SMILES Cn1cc(cn1)-c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1OCC(F)F

InChI Key InChIKey=GSCBTVAYMDWDTL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50581523   

TargetHigh affinity nerve growth factor receptor(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581523(CHEMBL5092943)
Affinity DataIC50: 14nMAssay Description:Inhibition of wildtype TRKA (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 40 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581523(CHEMBL5092943)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of TRKA GS95R mutant (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581523(CHEMBL5092943)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed