BDBM50582345 CHEMBL5083330

SMILES ONC(=O)CCCCCn1cc(Nc2ncc3ccn(Cc4ccccc4F)c3n2)cn1

InChI Key InChIKey=SIIPSHJEGRKPEI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50582345   

TargetTyrosine-protein kinase JAK2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50582345(CHEMBL5083330)
Affinity DataIC50: 10nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 60 mins followed by reagent A addition and measured after 60 mins in presence of ATP by using mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50582345(CHEMBL5083330)
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC6 (unknown origin) incubated for 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50582345(CHEMBL5083330)
Affinity DataIC50: 145nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated for 60 mins using microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50582345(CHEMBL5083330)
Affinity DataIC50: 32nMAssay Description:Inhibition of JAK1 (unknown origin) preincubated for 60 mins followed by reagent A addition and measured after 60 mins in presence of ATP by using mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50582345(CHEMBL5083330)
Affinity DataIC50: 18nMAssay Description:Inhibition of JAK3 (unknown origin) preincubated for 60 mins followed by reagent A addition and measured after 60 mins in presence of ATP by using mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50582345(CHEMBL5083330)
Affinity DataIC50: 13nMAssay Description:Inhibition of TYK2 (unknown origin) incubated for 40 min in presence of ATP by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed