BDBM50582513 CHEMBL5093161
SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2CO[P@](S)(=O)O[C@@H]3[C@H](O)[C@@H](CO[P@](S)(=O)O[C@H]2[C@H]1O)O[C@H]3n1cnc2c(N)ncnc12
InChI Key InChIKey=IZJJFUQKKZFVLH-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50582513
Affinity DataEC50: 860nMAssay Description:Agonist activity at human STING expressed in human THP-1 cells expressing IRF inducible SEAP reporter construct assessed as increase in interferon pr...More data for this Ligand-Target Pair
Affinity DataKd: 620nMAssay Description:Binding affinity to recombinant human Avi-tagged wild type STING (149 to 379 residues) expressed in Escherichia coli BL21 DE3 assessed as dissociatio...More data for this Ligand-Target Pair
Affinity DataKd: 30nMAssay Description:Binding affinity to recombinant human wild type STING (155 to 341 residues) expressed in Escherichia coli BL21 DE3 assessed as dissociation constant ...More data for this Ligand-Target Pair
Affinity DataEC50: 7.90E+3nMAssay Description:Agonist activity at human STING expressed in mouse RAW cells expressing IRF inducible SEAP reporter construct assessed as increase in interferon prod...More data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at human STING in STING knockout human THP1-Blue ISG cells expressing IRF inducible SEAP reporter construct assessed as increase in ...More data for this Ligand-Target Pair
Affinity DataEC50: 5.97E+3nMAssay Description:Agonist activity at human wild type STING overexpressed in STING knockout human THP1-Blue ISG cells expressing IRF inducible SEAP reporter construct ...More data for this Ligand-Target Pair
Affinity DataEC50: 700nMAssay Description:Binding affinity to human STING incubated for 60 mins measured by competitive TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataEC50: 5.34E+3nMAssay Description:Agonist activity at STING in human THP1-Dual cells assessed as ISG pathway activation incubated for 24 hrs by Quanti-Luc or Quanti-blue reagent based...More data for this Ligand-Target Pair
Affinity DataEC50: 3.32E+3nMAssay Description:Agonist activity at human wild type full length STING expressed in 293T cells incubated for 7 hrs by luciferase/cell based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 80nMAssay Description:Agonist activity at human wild type STING expressed in 293T cells by digitonin cell based assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mouse)
Takeda Pharmaceuticals International
Curated by ChEMBL
Takeda Pharmaceuticals International
Curated by ChEMBL
Affinity DataEC50: 7.38E+3nMAssay Description:Agonist activity at STING in mouse RAW264.7 cells incubated for 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mouse)
Takeda Pharmaceuticals International
Curated by ChEMBL
Takeda Pharmaceuticals International
Curated by ChEMBL
Affinity DataEC50: 7.16E+3nMAssay Description:Agonist activity at mouse STING in THP-1 dual cells incubated for 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at STING KO human THP-1 dual cells incubated for 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair