BDBM50583325 CHEMBL5093245::US12208088, Compound 27

SMILES CN(C)C(=O)c1c(N)ccc(c1F)-c1cnc2NCC3(CCCC3)c2c1Cl

InChI Key InChIKey=HPLDWJVEVHEYKM-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50583325   

LigandPNGBDBM50583325(CHEMBL5093245 | US12208088, Compound 27)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of HPK1 in human Jurkat E6.1 cells assessed as SLP76 phosphorylation incubated for 30 mins followed by anti-CD3, biotinylated anti-SLP76 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50583325(CHEMBL5093245 | US12208088, Compound 27)
Affinity DataIC50: 800nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate by TDI- high-throughput based mass spectrometry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50583325(CHEMBL5093245 | US12208088, Compound 27)
Affinity DataKi:  2.5nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50583325(CHEMBL5093245 | US12208088, Compound 27)
Affinity DataKi:  6.71nMAssay Description:For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2025
Entry Details
Go to US Patent