BDBM50584285 CHEMBL5075214

SMILES Cc1c(Nc2nc3[C@@H](O)CCCc3s2)cc(Cl)cc1OC1CCN(CC1)C(=O)CC(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=AFZMZLHHVUIZBS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50584285   

TargetNuclear receptor ROR-gamma(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50584285(CHEMBL5075214)
Affinity DataIC50: 98nMAssay Description:Inhibition of human GAL4-fused RORgammat LBD transfected in HEK293T cell measured after 24 hrs by by dual-glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50584285(CHEMBL5075214)
Affinity DataIC50: 149nMAssay Description:Inhibition of human APC-labeled RORgammat LBD (262 to 518 residues) transfected in Escherichia coli BL21 (DE3) assessed as biotinylated SRC recruitme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50584285(CHEMBL5075214)
Affinity DataIC50: 432nMAssay Description:Inhibition of human recombinant DHODH expressed in Escherichia coli BL21 (DE3) using dihydroorotate as substrate and CoQ6 as co-substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed