BDBM50584331 CHEMBL5079796

SMILES FC1COCC1N1CCC(C(F)C1)c1cc2nc(Nc3cnn(C4CC4(F)F)c3Cl)ncc2cc1Cl

InChI Key InChIKey=KRFJRUPKPPEOCI-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50584331   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck

Curated by ChEMBL

LigandBDBM50584331(CHEMBL5079796)Copy SMILESCopy InChI

Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) preincubated with enzyme for 15 mins follo...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/6/2023
Entry Details Article
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck

Curated by ChEMBL

LigandBDBM50584331(CHEMBL5079796)Copy SMILESCopy InChI

Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of human ERG by voltage clamp assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/6/2023
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL