BDBM50584332 CHEMBL5076397

SMILES c1c2cnc(nc2cc(c1Cl)[C@@H]3CCN(C[C@H]3F)[C@@H]4COC[C@@H]4O)Nc5cnn(c5Cl)[C@@H]6CC6(F)F

InChI Key InChIKey=JCYBYWFFRFKLHB-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50584332   

LigandPNGBDBM50584332(CHEMBL5076397)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) preincubated with enzyme for 15 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50584332(CHEMBL5076397)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50584332(CHEMBL5076397)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of tachykinin NK1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50584332(CHEMBL5076397)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of human ERG by voltage clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed