BDBM50584949 CHEMBL5089164

SMILES Cn1ccc2cc(Nc3ncc(c(N[C@@H]4CC[C@H](N)CC4)n3)C(F)(F)F)ccc2c1=O

InChI Key InChIKey=LSEAQLOYCHTEOK-UHFFFAOYSA-N

Data  21 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50584949   

TargetCyclin-dependent kinase 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 830nMAssay Description:Inhibition of human recombinant CDK2 incubated for 1 hrs by HTRF KinEASE TK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 26nMAssay Description:Inhibition of CHK1 (unknown origin) using peptide substrate S1 and ATP as substrate incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin) using peptide substrate TK-S and ATP as substrate incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of wild type FLT3 (unknown origin) using peptide substrate TK-S and ATP as substrate incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataEC50: <1nMAssay Description:Inhibition of FLT3 downstream signalling in human MV4-11 cells assessed as reduction in autophosphorylation at tyr589/591 residue for 90 mins by West...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 2.34E+3nMAssay Description:Inhibition of human recombinant ALK incubated for 1 hrs by HTRF KinEASE TK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 4.53E+3nMAssay Description:Inhibition of N-terminal GST tagged human recombinant cKit (544 residue) expressed in baculovirus infected Sf21 insect cells using TK peptide as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of N-terminal GST tagged human recombinant FLT3 D835Y mutant (564 residue) expressed in baculovirus infected Sf21 insect cells using TK pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of N-terminal GST tagged human recombinant wild type FLT-3 (564-993 residues) expressed in baculovirus infected Sf21 insect cells using TK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 2.67E+3nMAssay Description:Inhibition of human recombinant CDK6 incubated for 1 hrs by HTRF KinEASE TK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of human recombinant CDK1 incubated for 1 hrs by HTRF KinEASE TK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human recombinant C terminal hFc tagged FLT3 (Asn27-Ser543 residues) expressed in HEK293 cells incubated for 1 hrs by HTRF KinEASE TKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant EGFR incubated for 1 hrs by HTRF KinEASE TK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 393nMAssay Description:Inhibition of human recombinant EPHA1 incubated for 1 hrs by HTRF KinEASE TK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 225nMAssay Description:Inhibition of human recombinant JAK3 incubated for 1 hrs by HTRF KinEASE TK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetWee1-like protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant WEE1 incubated for 1 hrs by HTRF KinEASE TK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 37nMAssay Description:Inhibition of human recombinant AURKA incubated for 1 hrs by HTRF KinEASE TK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 860nMAssay Description:Inhibition of human recombinant PAK1 incubated for 1 hrs by HTRF KinEASE TK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant BTK incubated for 1 hrs by HTRF KinEASE TK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 919nMAssay Description:Inhibition of human recombinant IGF1R incubated for 1 hrs by HTRF KinEASE TK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 607nMAssay Description:Inhibition of human recombinant BMX incubated for 1 hrs by HTRF KinEASE TK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant TRKA incubated for 1 hrs by HTRF KinEASE TK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed