BDBM50584979 CHEMBL5086374

SMILES N[C@H]1CC[C@H](CC1)Nc1nc(Nc2ccc3C(=O)NCc3c2)ncc1C(F)(F)F

InChI Key InChIKey=USEARZGMRUHRRW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50584979   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584979(CHEMBL5086374)
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal GST tagged human recombinant wild type FLT-3 (564-993 residues) expressed in baculovirus infected Sf21 insect cells using TK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584979(CHEMBL5086374)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of N-terminal GST tagged human recombinant FLT3 D835Y mutant (564 residue) expressed in baculovirus infected Sf21 insect cells using TK pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50584979(CHEMBL5086374)
Affinity DataIC50: 5.15E+3nMAssay Description:Inhibition of N-terminal GST tagged human recombinant cKit (544 residue) expressed in baculovirus infected Sf21 insect cells using TK peptide as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed