BDBM50585541 CHEMBL5071942

SMILES NC(=O)[C@@H]1CCCN1C(=O)c1ccc(NC(=O)Nc2ccc(cc2)-c2nc(nc(n2)N2CCOCC2)N2CCOCC2)cc1

InChI Key InChIKey=XDXZHIQVJAQRGY-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50585541   

LigandPNGBDBM50585541(CHEMBL5071942)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate in presence of ATP incubated for 60 mins by ADP-glo based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50585541(CHEMBL5071942)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of mTOR (unknown origin) using U-Light-4E-BP1 peptide as a substrate in presence of ATP incubated for 45 mins by Lance ultra assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM50585541(CHEMBL5071942)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate in presence of ATP incubated for 60 mins by ADP-glo based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM50585541(CHEMBL5071942)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate in presence of ATP incubated for 60 mins by ADP-glo based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM50585541(CHEMBL5071942)
Affinity DataIC50: 27nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate in presence of ATP incubated for 60 mins by ADP-glo based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50585541(CHEMBL5071942)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG transfected in CHO cells by automated patch methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50585541(CHEMBL5071942)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50585541(CHEMBL5071942)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50585541(CHEMBL5071942)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50585541(CHEMBL5071942)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50585541(CHEMBL5071942)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed