BDBM50585561 CHEMBL5079397

SMILES [H][C@]12CN(C[C@]1([H])OCCO2)c1nc(nc(n1)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)N2CCC(CC2)N(C)C)cc1)N1CCOCC1

InChI Key InChIKey=DCEYPHCMQLDVQF-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50585561   

TargetSerine/threonine-protein kinase mTOR(Human)
Guizhou Medical University

Curated by ChEMBL

LigandBDBM50585561(CHEMBL5079397)Copy SMILESCopy InChI

Affinity DataIC50: 4.80nMAssay Description:Inhibition of mTOR (unknown origin) using U-Light-4E-BP1 peptide as a substrate in presence of ATP incubated for 45 mins by Lance ultra assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/7/2023
Entry Details Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Guizhou Medical University

Curated by ChEMBL

LigandBDBM50585561(CHEMBL5079397)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate in presence of ATP incubated for 60 mins by ADP-glo based luminescence assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/7/2023
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL