BDBM50585748 CHEMBL5086240

SMILES CC(C)(C)OC(=O)CC(O)\C=C\CCSSCC\C=C\C(O)CC(=O)OC(C)(C)C

InChI Key InChIKey=ZOTJPWIOCKAMRG-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50585748   

TargetHistone deacetylase 3(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50585748(CHEMBL5086240)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of HDAC3 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50585748(CHEMBL5086240)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of HDAC1 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50585748(CHEMBL5086240)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC2 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50585748(CHEMBL5086240)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full-length HDAC2 preincubated for 20 mins with DTT followed by enzyme addition and measured after 10 mins by Glo-lum...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50585748(CHEMBL5086240)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of HDAC8 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50585748(CHEMBL5086240)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of HDAC6 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50585748(CHEMBL5086240)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human full-length HDAC2 incubated for 10 mins by Glo-luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed