BDBM50585893 CHEMBL5078078

SMILES CC(C)(O)c1ccc(cc1)N1Cc2c(ccnc2-c2ccc(F)cc2OCC(F)(F)F)C1=O

InChI Key InChIKey=OAZAPIKYVGRNCO-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50585893   

TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585893(CHEMBL5078078)
Affinity DataIC50: 31nMAssay Description:Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Mouse)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585893(CHEMBL5078078)
Affinity DataIC50: 51nMAssay Description:Inhibition of mouse GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585893(CHEMBL5078078)
Affinity DataIC50: 310nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50585893(CHEMBL5078078)
Affinity DataEC50:  7.60nMAssay Description:Inhibition of GCS in GBA mutant human fibroblasts assessed as reduction in glucosylceramide level incubated for 4 days by RapdiFire-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed