BDBM50586386 CHEMBL5084878::US20240034730, Compound 16

SMILES COc1cccc(c1)-c1c(F)c(F)c(NC(=O)c2c(O)nn3ccccc23)c(F)c1F

InChI Key InChIKey=MOUXQJXFYIHZAV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50586386   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Drug Discovery and Clinic

US Patent
LigandPNGBDBM50586386(CHEMBL5084878 | US20240034730, Compound 16)
Affinity DataIC50: 2.75nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Drug Discovery and Clinic

US Patent
LigandPNGBDBM50586386(CHEMBL5084878 | US20240034730, Compound 16)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed