BDBM50586970 CHEMBL5074383

SMILES Cc1cc2cc(ccc2n1Cc1cccc(F)c1)C(=O)NCc1ccc(CS(=O)(=O)C2CC2)cc1C(F)(F)F

InChI Key InChIKey=KFKAORAIOHHVSN-UHFFFAOYSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50586970   

TargetBifunctional epoxide hydrolase 2(Human)
Goethe-University

Curated by ChEMBL
LigandPNGBDBM50586970(CHEMBL5074383)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant human full length sEH assessed as reduction in 6-methoxy-2-naphthaldehyde formation using PHOME as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University

Curated by ChEMBL
LigandPNGBDBM50586970(CHEMBL5074383)
Affinity DataEC50:  150nMAssay Description:Partial agonist activity at GAL4-tagged human PPARgamma LBD expressed in HEK293T cells incubated for 12 to 14 hrs by dual-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Mouse)
Goethe-University

Curated by ChEMBL
LigandPNGBDBM50586970(CHEMBL5074383)
Affinity DataIC50: 176nMAssay Description:Inhibition of N-terminal His-tagged mouse sEH (2 to 554 residues) expressed in Escherichia coli Rosetta2 (DE3) assessed as reduction in 6-methoxy-2-n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University

Curated by ChEMBL
LigandPNGBDBM50586970(CHEMBL5074383)
Affinity DataEC50:  180nMAssay Description:Partial agonist activity at sGSF-PPARgamma (unknown origin) assessed as CBP-1 recruitment by HT-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University

Curated by ChEMBL
LigandPNGBDBM50586970(CHEMBL5074383)
Affinity DataIC50: 650nMAssay Description:Partial agonist activity at recombinant sGSF-PPARgamma (unknown origin) assessed as reduction in rosiglitazone induced CBP-1 recruitment incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed