BDBM50587763 CHEMBL5183336

SMILES C[C@@H](C(O)=O)c1ccccc1-c1cc2n(cnc2cn1)[C@H](C)c1c(Cl)ccc(C2CC2)c1Cl

InChI Key InChIKey=JPJWHCNGSBCZMI-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50587763   

TargetGlucagon-like peptide 1 receptor(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50587763(CHEMBL5183336)
Affinity DataEC50:  0.0850nMAssay Description:Agonist activity at human GLP-1R expressed in HEK293 cells assessed as potentiation of GLP-1(7-36) induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50587763(CHEMBL5183336)
Affinity DataEC50:  7nMAssay Description:Agonist activity at human GLP-1R expressed in HEK293 cells assessed as potentiation of GLP-1(9-36) induced cAMP accumulation in presence of IBMXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50587763(CHEMBL5183336)
Affinity DataEC50:  7nMAssay Description:Positive allosteric modulator activity at human GLP-1R transfected in rat INS-1 832/13 cells assessed as potentiation of GLP-1(9-36) induced cAMP acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50587763(CHEMBL5183336)
Affinity DataEC50:  12nMAssay Description:Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as potentiation of GLP-1(9-36) induced beta-arrestin recruitmentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50587763(CHEMBL5183336)
Affinity DataEC50:  270nMAssay Description:Positive allosteric modulator activity at human GLP-1R expressed in HEK293 cells assessed as potentiation of EC20 GLP-1(9-36) induced cAMP accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50587763(CHEMBL5183336)
Affinity DataEC50:  1.80E+3nMAssay Description:Partial agonist activity at human GLP-1R expressed in HEK293 cells assessed as potentiation of GLP-1(9-36) induced cAMP accumulation in presence of I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed