BDBM50588245 CHEMBL5172947::US11702392, Compound 2b

SMILES CC1(N)CCN(CC1)c1cc(=O)n(c(N)n1)-c1cccc(Cl)c1Cl

InChI Key InChIKey=ARBJGNWDHYZZEL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50588245   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM50588245(CHEMBL5172947 | US11702392, Compound 2b)
Affinity DataIC50: 180nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM50588245(CHEMBL5172947 | US11702392, Compound 2b)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed