BDBM50588430 CHEMBL5203629

SMILES Cc1c(C)c(nnc1N1CCC(CC1)NC(=O)Nc1ccc(Oc2nc(NC3CCOCC3)ncc2Cl)cc1)-c1cnn(C)c1

InChI Key InChIKey=UAHVYJLPWRAFAS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50588430   

TargetMitogen-activated protein kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50588430(CHEMBL5203629)
Affinity DataIC50: 41nMAssay Description:Inhibition of ERK2 (unknown origin) using kinase substrate 8 incubated for 40 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSmoothened homolog(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50588430(CHEMBL5203629)
Affinity DataIC50: 409nMAssay Description:Inhibition of SMO in mouse 3T3/HH FlashII-7 cells incubated for 36 hrs in presence of SHH by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed