BDBM50589206 CHEMBL5184084

SMILES CC(C)(\C=C(\C#N)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc12)N1CCOCC1

InChI Key InChIKey=NZIQNLGMMJGSQU-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50589206   

TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589206(CHEMBL5184084)
Affinity DataIC50: 72nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589206(CHEMBL5184084)
Affinity DataIC50: 36nMAssay Description:Inhibition of biotinylated-labeled BTK-selective probe binding to BTK in human Ramos assessed as target occupancy pretreated for 1 hr followed by pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase Blk(Human)
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589206(CHEMBL5184084)
Affinity DataIC50: 92nMAssay Description:Inhibition of BLK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589206(CHEMBL5184084)
Affinity DataIC50: 10nMAssay Description:Inhibition of BMX (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589206(CHEMBL5184084)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of EGFR (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589206(CHEMBL5184084)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of ERBB2 (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589206(CHEMBL5184084)
Affinity DataIC50: 177nMAssay Description:Inhibition of ERBB4 (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589206(CHEMBL5184084)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of ITK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589206(CHEMBL5184084)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of JAK3 (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase Tec(Human)
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589206(CHEMBL5184084)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of TEC (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase TXK(Human)
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589206(CHEMBL5184084)
Affinity DataIC50: 45nMAssay Description:Inhibition of RLK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed