BDBM50589680 CHEMBL5195204

SMILES Cc1c(ccc(n1)NC(=O)NC(=O)C(C)(C)C)Oc2ccnc(c2)c3cnn(c3)C

InChI Key InChIKey=WYLCQKJYTVNVCY-UHFFFAOYSA-N

Data  11 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50589680   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589680(CHEMBL5195204)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589680(CHEMBL5195204)
Affinity DataIC50: 216nMAssay Description:Inhibition of N-terminal GST-tagged PDGFRalpha (unknown origin) (550 to 1089 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589680(CHEMBL5195204)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of N-terminal GST-tagged PDGFRbeta (unknown origin) (557 to 1106 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589680(CHEMBL5195204)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of VEGFR2 (unknown origin) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589680(CHEMBL5195204)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of His-tagged recombinant human FLT3 (564 to 958 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589680(CHEMBL5195204)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of N-terminal His-Glu-TEV-tagged MET (unknown origin) (1050 to 1360 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589680(CHEMBL5195204)
Affinity DataIC50: 5.25E+3nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589680(CHEMBL5195204)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589680(CHEMBL5195204)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589680(CHEMBL5195204)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589680(CHEMBL5195204)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed