BDBM50589860 CHEMBL5183142

SMILES CC(C)C[C@H](NC(=O)CNC(=O)CC[C@H](NS(=O)(=O)c1ccc(Cl)c(c1)C(F)(F)F)C(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(N)=O

InChI Key InChIKey=XHPNKAPWXFVQKQ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50589860   

TargetMatrilysin(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50589860(CHEMBL5183142)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant MMP-7 (Leu18 to Lys267 residues) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMatrix metalloproteinase-14(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50589860(CHEMBL5183142)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human recombinant C-terminal 10-His tagged MMP-14 ( Ala21 to Gly284 residues) using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMacrophage metalloelastase(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50589860(CHEMBL5183142)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human recombinant MMP-12 (Leu17 to Cys470 residues) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50589860(CHEMBL5183142)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human recombinant MMP-2 ( Ile34 to Cys660 residues) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCollagenase 3(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50589860(CHEMBL5183142)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant MMP-13 (Leu20 to Cys471 residues) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNeutrophil collagenase(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50589860(CHEMBL5183142)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant MMP-8 (Phe21 to Gly467 residues) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50589860(CHEMBL5183142)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant MMP-1 (Phe20 to Asn469 residue) using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50589860(CHEMBL5183142)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant MMP-9 (Ala20 to Asp707 residues) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetStromelysin-1(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50589860(CHEMBL5183142)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant MMP-3 (Tyr18 to Cys477 residues ) using MOCAc-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as fluorogenic substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed