BDBM50591184 CHEMBL5172973

SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)C4CC4)c3)c2n1)N1CCN(CCCCCCCCCCCCNC(=O)CC23CC4CC(CC(C4)C2)C3)CC1

InChI Key

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50591184   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50591184(CHEMBL5172973)
Affinity DataEC50: >1.00E+3nMAssay Description:Induction of AKT1 degradation in human NCI-H1975 cells assessed as reduction in AKT1 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50591184(CHEMBL5172973)
Affinity DataEC50: >1.00E+3nMAssay Description:Induction of AKT2 degradation in human NCI-H1975 cells assessed as reduction in AKT2 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50591184(CHEMBL5172973)
Affinity DataEC50:  13nMAssay Description:Induction of AKT3 degradation in human NCI-H1975 cells assessed as reduction in AKT3 protein level incubated for 24 hrs under serum free medium by We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50591184(CHEMBL5172973)
Affinity DataEC50:  579nMAssay Description:Inhibition of EGFR in human NCI-H1975 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed