BDBM50591644 CHEMBL5206589

SMILES ONC(=O)CCCCCNC(=O)c1cccc2cc3ccccc3nc12

InChI Key InChIKey=IQSOIKNMFKWXSR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50591644   

TargetHistone deacetylase 1(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50591644(CHEMBL5206589)
Affinity DataIC50: 17nMAssay Description:Inhibition of His-tagged recombinant human HDAC1 (482 residues) expressed in baculovirus infected insect cells using FLUOR DE LYS-SIRT1 as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50591644(CHEMBL5206589)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of His-tagged recombinant human HDAC6 expressed in baculovirus infected insect cells using Boc-Lys(Ac)-AMC as substrate preincubated for 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50591644(CHEMBL5206589)
Affinity DataIC50: 17nMAssay Description:Inhibition of HDAC-1 (unknown origin) expressed in Escherichia coli BL21 (DE3) in HeLa nuclear extract using KI177 as substrate preincubated for 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50591644(CHEMBL5206589)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of HDAC-6 (unknown origin) expressed in Escherichia coli BL21 (DE3) in HeLa nuclear extract using Boc-Lys(TFA)-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed