BDBM50592188 CHEMBL5176490

SMILES N[C@H]1CCN(C1)c1c(cncc1-c1cc(F)cc(Cl)c1)-c1nc2c(F)cccc2[nH]1

InChI Key InChIKey=KNURDJSPJNPJSP-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50592188   

TargetSomatostatin receptor type 5(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592188(CHEMBL5176490)
Affinity DataEC50:  0.251nMAssay Description:Agonist activity at human SST5 expressed in CHO-K1 cells assessed as reduction in NKH477-induced intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSomatostatin receptor type 5(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592188(CHEMBL5176490)
Affinity DataEC50:  0.270nMAssay Description:Agonist activity at human SST5 expressed in CHO-K1 cells assessed as reduction in NKH477-induced intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592188(CHEMBL5176490)
Affinity DataIC50: 90nMAssay Description:Time dependent inhibition of CYP2D6 (unknown origin) preincubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50592188(CHEMBL5176490)
Affinity DataIC50: 400nMAssay Description:Time dependent inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed