BDBM50592753 CHEMBL5203385

SMILES CCc1cc(Nc2ncc(Br)c(Nc3ccc4OCCOc4c3P(C)(C)=O)n2)c(OC)cc1N1CCC(CC1)N1CC(CC#N)C1

InChI Key InChIKey=SHLMQOCQLLXCPJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50592753   

TargetEpidermal growth factor receptor(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50592753(CHEMBL5203385)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of EGFR del18/T790M/C797S triple mutant (unknown origin) using TK as substrate incubated for 120 mins in the presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50592753(CHEMBL5203385)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using TK as substrate incubated for 120 mins in the presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50592753(CHEMBL5203385)
Affinity DataIC50: 416nMAssay Description:Inhibition of wild type EGFR (unknown origin) using TK as substrate incubated for 120 mins in the presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed