BDBM50593067 CHEMBL3408216

SMILES Cn1ncc2cc(ccc12)-c1cncc(Cl)c1N1CCC2(CCNC2=O)CC1

InChI Key InChIKey=VIEYRTKHMAJVMI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50593067   

TargetCyclin-dependent kinase 8(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50593067(CHEMBL3408216)
Affinity DataIC50: 18nMAssay Description:Inhibition of CDK8 (unknown origin) incubated in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 8(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50593067(CHEMBL3408216)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CDK8 in human HCT-116 cells transfected with TOPFlash luciferase reporter plasmid assessed as reduction in TCF/LEF transcriptional acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed