BDBM50593154 CHEMBL5206534

SMILES Cc1cccc2sc(NC(=O)CCN3CCN(CC3)c3ccncc3)nc12

InChI Key InChIKey=SPXJUIUQOLDKNX-UHFFFAOYSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50593154   

TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593154(CHEMBL5206534)
Affinity DataKi:  184nMAssay Description:Displacement of [3H]ifenprodil from recombinant human GluN2B NMDA receptor (unknown origin) expressed in dexamethasone-induced mouse L-M(TK-) cell af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593154(CHEMBL5206534)
Affinity DataIC50: 1.13E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as reduction in YO-PRO-1 iodide dye uptake preincubated for 30 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593154(CHEMBL5206534)
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) preincubated for 10 mins followed by NADP addition measured after 50 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593154(CHEMBL5206534)
Affinity DataKi:  1.70E+3nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593154(CHEMBL5206534)
Affinity DataIC50: 2.46E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin) preincubated for 10 mins followed by NADP addition measured after 50 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593154(CHEMBL5206534)
Affinity DataKi:  9.60E+3nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593154(CHEMBL5206534)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin) preincubated for 10 mins followed by NADP addition measured after 50 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593154(CHEMBL5206534)
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of human recombinant AChe using acetylthiocholine iodide as substrate incubated for 10 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCholinesterase(Human)
Yeditepe University

Curated by ChEMBL
LigandPNGBDBM50593154(CHEMBL5206534)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant BuChe using butyrylthiocholine iodide as substrate incubated for 10 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed