BDBM50593565 CHEMBL5193039

SMILES Nc1ncc(nc1C(=O)NC12CCC(O)(CC1)CC2)-c1ccc(CN2CCC(CC2)N2CCOCC2)cc1Cl

InChI Key InChIKey=RIGIHWPKCOSNDD-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50593565   

TargetActivin receptor type-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50593565(CHEMBL5193039)
Affinity DataIC50: 8nMAssay Description:Inhibition of ALK2 R206H mutant (unknown origin) assessed as enzymatic activity by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50593565(CHEMBL5193039)
Affinity DataIC50: 44nMAssay Description:Inhibition of ALK2 R206H mutant (unknown origin) transfected in BMP6-stimulated human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50593565(CHEMBL5193039)
Affinity DataIC50: 12nMAssay Description:Inhibition of wild type ALK2 (unknown origin) assessed as enzymatic activity by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50593565(CHEMBL5193039)
Affinity DataIC50: 120nMAssay Description:Inhibition of wild type ALK1 (unknown origin) assessed as enzymatic activity by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1A(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50593565(CHEMBL5193039)
Affinity DataIC50: 280nMAssay Description:Inhibition of wild type ALK3 (unknown origin) assessed as enzymatic activity using chemiluminescent substrate by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50593565(CHEMBL5193039)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of wild type ALK5 (unknown origin) assessed as enzymatic activity by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50593565(CHEMBL5193039)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of wild type ALK6 (unknown origin) assessed as enzymatic activity using chemiluminescent substrate by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed