BDBM50594223 CHEMBL5195670

SMILES Nc1ncnc2n(C3CCN(C3)C(=O)C=C)c(=O)n(-c3ccc(Oc4ccccc4)cc3)c12

InChI Key InChIKey=BACWTDCVYNWWBX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50594223   

TargetTyrosine-protein kinase BTK(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50594223(CHEMBL5195670)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of His-tagged full-length recombinant wild-type human BTK (Ala2 to Ser659 residues) expressed in baculovirus infected insect cells incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50594223(CHEMBL5195670)
Affinity DataIC50: 174nMAssay Description:Inhibition of BTK C481S mutant (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for 30 mins in presence of ATP by Microf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50594223(CHEMBL5195670)
Affinity DataIC50: 345nMAssay Description:Inhibition of BTK T474I mutant (unknown origin) expressed in baculovirus infected Trichoplusia ni pro cells incubated for 30 mins in presence of ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50594223(CHEMBL5195670)
Affinity DataIC50: 703nMAssay Description:Inhibition of BTK C481R mutant (unknown origin) expressed in baculovirus infected Trichoplusia ni pro cells incubated for 30 mins in presence of ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50594223(CHEMBL5195670)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BTK T474M mutant (unknown origin) expressed in baculovirus infected Trichoplusia ni pro cells incubated for 30 mins in presence of ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed