BDBM50594225 CHEMBL5198054

SMILES CC#CC(=O)N1CCCC1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12

InChI Key InChIKey=WDENQIQQYWYTPO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50594225   

TargetTyrosine-protein kinase BTK(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50594225(CHEMBL5198054)
Affinity DataIC50: 18nMAssay Description:Inhibition of His-tagged full-length recombinant wild-type human BTK (Ala2 to Ser659 residues) expressed in baculovirus infected insect cells incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50594225(CHEMBL5198054)
Affinity DataIC50: 207nMAssay Description:Inhibition of BTK T474I mutant (unknown origin) expressed in baculovirus infected Trichoplusia ni pro cells incubated for 30 mins in presence of ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50594225(CHEMBL5198054)
Affinity DataIC50: 247nMAssay Description:Inhibition of BTK C481S mutant (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for 30 mins in presence of ATP by Microf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50594225(CHEMBL5198054)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BTK C481R mutant (unknown origin) expressed in baculovirus infected Trichoplusia ni pro cells incubated for 30 mins in presence of ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50594225(CHEMBL5198054)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BTK T474M mutant (unknown origin) expressed in baculovirus infected Trichoplusia ni pro cells incubated for 30 mins in presence of ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed