BDBM50594760 CHEMBL5203044

SMILES [H][C@@]12CC(c3cc(=O)[nH]c4n[nH]c(C)c34)[C@@]([H])(C[C@@H]1CC#N)C2

InChI Key InChIKey=KGKZRAAHCZTDQA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50594760   

TargetTyrosine-protein kinase JAK1(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50594760(CHEMBL5203044)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal GST-tagged human JAK1 (850 to 1154 residues) expressed in baculovirus expression system using TK-substrate-biotin as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50594760(CHEMBL5203044)
Affinity DataIC50: 100nMAssay Description:Inhibition of JAK1 in human STAT6-bla RA-1 cells assessed as reduction in IL-4 induced STAT6 phosphorylation preincubated for 1 hr followed by IL-4 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed