BDBM50595922 CHEMBL4303389

SMILES C[C@H](Nc1cc(cc(Nc2cnccn2)n1)-c1cnn(C)c1)c1ccc(F)cc1

InChI Key InChIKey=UQTPDWDAYHAZNT-UHFFFAOYSA-N

Data  13 IC50  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50595922   

TargetTyrosine-protein kinase JAK1(Human)
Tampere University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataIC50: 7.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Zhengzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataIC50: 39nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Zhengzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataIC50: 22nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Tampere University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataIC50: 33nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Tampere University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataIC50: 41nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Tampere University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Zhengzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataIC50: 216nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Zhengzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataIC50: 182nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Tampere University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataIC50: 0.800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Tampere University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of JAK 2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Zhengzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataKd:  21nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Zhengzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataKd:  19nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Tampere University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataKd:  4.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Tampere University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataKd:  16nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Zhengzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataIC50: 22nMAssay Description:Inhibition of human TYK2 kinase domain incubated for 1 hrs in the presence of ATP by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Zhengzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataIC50: 39nMAssay Description:Inhibition of human JAK3 kinase domain incubated for 1 hrs in the presence of ATP by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Tampere University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataIC50: 0.720nMAssay Description:Inhibition of human JAK2 kinase domain incubated for 1 hrs in the presence of ATP by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Tampere University

Curated by ChEMBL
LigandPNGBDBM50595922(CHEMBL4303389)
Affinity DataIC50: 33nMAssay Description:Inhibition of human JAK1 kinase domain incubated for 1 hrs in the presence of ATP by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed