BDBM50598708 CHEMBL5189603::US20230348487, Example LS 5-77

SMILES [H][C@]12OC[C@@H](Oc3nc(Nc4cccc(NC(=O)C=C)c4)ncc3Cl)[C@@]1([H])OC[C@H]2O

InChI Key InChIKey=HUFMEHAQXLWBMX-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50598708   

TargetTyrosine-protein kinase JAK1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598708(CHEMBL5189603 | US20230348487, Example LS 5-77)
Affinity DataIC50: 556nMAssay Description:Inhibition of GST-tagged recombinant human JAK1 (866 to 1154 residues) expressed in baculovirus infection system by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598708(CHEMBL5189603 | US20230348487, Example LS 5-77)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of GST tagged recombinant human JAK2 expressed in baculovirus infection system by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598708(CHEMBL5189603 | US20230348487, Example LS 5-77)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of GST tagged recombinant human JAK3 expressed in baculovirus infection system by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598708(CHEMBL5189603 | US20230348487, Example LS 5-77)
Affinity DataIC50: 94nMAssay Description:Inhibition of human TYK2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598708(CHEMBL5189603 | US20230348487, Example LS 5-77)
Affinity DataIC50: 556nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598708(CHEMBL5189603 | US20230348487, Example LS 5-77)
Affinity DataIC50: 1.40E+3nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598708(CHEMBL5189603 | US20230348487, Example LS 5-77)
Affinity DataIC50: 1.25nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598708(CHEMBL5189603 | US20230348487, Example LS 5-77)
Affinity DataIC50: 93.9nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598708(CHEMBL5189603 | US20230348487, Example LS 5-77)
Affinity DataIC50: 2.39nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent