BDBM50598722 CHEMBL5192736::US20230348487, Example LS 6-105

SMILES [H][C@]12OCC(F)(F)[C@@]1([H])OC[C@H]2Oc1nc(Nc2ccc(N(C)CCN(C)C)c(NC(=O)C=C)c2)ncc1Cl

InChI Key InChIKey=TXDDTUVDXDRFAO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50598722   

TargetTyrosine-protein kinase JAK3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598722(CHEMBL5192736 | US20230348487, Example LS 6-105)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of GST tagged recombinant human JAK3 expressed in baculovirus infection system by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Guangzhou Salustier Biosciences

US Patent
LigandPNGBDBM50598722(CHEMBL5192736 | US20230348487, Example LS 6-105)
Affinity DataIC50: 4.22E+3nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Guangzhou Salustier Biosciences

US Patent
LigandPNGBDBM50598722(CHEMBL5192736 | US20230348487, Example LS 6-105)
Affinity DataIC50: 589nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598722(CHEMBL5192736 | US20230348487, Example LS 6-105)
Affinity DataIC50: 1.13nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Guangzhou Salustier Biosciences

US Patent
LigandPNGBDBM50598722(CHEMBL5192736 | US20230348487, Example LS 6-105)
Affinity DataIC50: 272nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598722(CHEMBL5192736 | US20230348487, Example LS 6-105)
Affinity DataIC50: 1.32nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent