BDBM50601458 CHEMBL5197174

SMILES CN1CCN(CC1)c1ccc(Nc2nc(Nc3ccc(F)c(F)c3)c3ncn(CC4CC4)c3n2)cc1

InChI Key InChIKey=FSURZKWYYKTGLY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50601458   

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Pla Strategic Support Force Medical Center

Curated by ChEMBL
LigandPNGBDBM50601458(CHEMBL5197174)
Affinity DataIC50: 40nMAssay Description:Inhibition of BCR-ABL (unknown origin) using peptide GGEAIYAAPFKK as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Pla Strategic Support Force Medical Center

Curated by ChEMBL
LigandPNGBDBM50601458(CHEMBL5197174)
Affinity DataIC50: 580nMAssay Description:Inhibition of BTK (unknown origin) using Poly(Glu4,Tyr1) as substrate in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Pla Strategic Support Force Medical Center

Curated by ChEMBL
LigandPNGBDBM50601458(CHEMBL5197174)
Affinity DataIC50: 580nMAssay Description:Inhibition of BTK (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50601458(CHEMBL5197174)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of ABL1 (unknown origin) using GGEAIYAAPFKK as substrate in the presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed