BDBM50601642 CHEMBL5188533

SMILES B([C@H](Cc1cccc(c1)CC)NC(=O)[C@H](Cc2ccccc2)NC(=O)c3cnccn3)(O)O

InChI Key InChIKey=RQXXOBNVVACHIB-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50601642   

TargetProteasome subunit beta type-9(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601642(CHEMBL5188533)
Affinity DataIC50: 11nMAssay Description:Inhibition of human 20S immunoproteasome beta-1i subunit using (Ac-PAL)2R110 as substrate preincubated for 2 hrs followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-10(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601642(CHEMBL5188533)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human 20S immunoproteasome beta-2i subunit using Ac-RLR-AMC as substrate preincubated for 2 hrs followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601642(CHEMBL5188533)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601642(CHEMBL5188533)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of human 20S immunoproteasome beta1 subunit using Ac-nLPnLD-AMC as substrate preincubated for 2 hrs followed by substrate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-7(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601642(CHEMBL5188533)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human 20S proteasome beta2 subunit using Ac-RLR-AMC as substrate preincubated for 2 hrs followed by substrate addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601642(CHEMBL5188533)
Affinity DataIC50: 41nMAssay Description:Inhibition of human 20S proteasome beta5 subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed