BDBM50602518 CHEMBL5206156

SMILES CC(C)S(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1ccn2nc(N)c(C(=O)NC3CC3)c2n1

InChI Key InChIKey=SGRQFHRGTVOPPV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50602518   

LigandPNGBDBM50602518(CHEMBL5206156)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate preincubated for 1 hr followed by substrate addition and measured after 60 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM50602518(CHEMBL5206156)
Affinity DataIC50: 51nMAssay Description:Inhibition of PI3Kgamma (unknown origin) in rhMPC1 stimulated human THP-1 cells assessed as reduction in Akt phosphorylation level at Ser473 residue ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM50602518(CHEMBL5206156)
Affinity DataIC50: 714nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 1 hr followed by substrate addition and measured after 60 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM50602518(CHEMBL5206156)
Affinity DataIC50: 952nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate preincubated for 1 hr followed by substrate addition and measured after 60 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50602518(CHEMBL5206156)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes at 40 uM using diclofenac as substrate measured after 5 to 20 mins in presence of NADPH by LC/MS/MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50602518(CHEMBL5206156)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes at 40 uM using midazolam as substrate measured after 5 to 20 mins in presence of NADPH by LC/MS/MS ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed