BDBM50602997 CHEMBL5182980

SMILES [O-][N+](=O)c1cc(ccc1Nc1ccc2[nH]nc(-c3ccncc3)c2c1)C#N

InChI Key InChIKey=GSPRDGGZFQZUBY-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50602997   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50602997(CHEMBL5182980)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of full length LRRK2 G2019S mutant (unknown origin) by LRRKtide Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50602997(CHEMBL5182980)
Affinity DataIC50: 23nMAssay Description:Inhibition of full length wild type LRRK2 (unknown origin) by LRRKtide Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50602997(CHEMBL5182980)
Affinity DataEC50:  1.40E+3nMAssay Description:Inhibition of pcDNA5FRT-TO-GFP fused - LRRK2 G2019S mutant (unknown origin) transfected in HEK293 cells incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50602997(CHEMBL5182980)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of wild type pcDNA5FRT-TO-GFP fused - LRRK2 (unknown origin) transfected in HEK293 cells incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed