BDBM50603132 CHEMBL5171962

SMILES OC(=O)c1ccc2CC3(CC3)c3nc(OCc4c(onc4-c4c(Cl)cccc4Cl)C4CC4)ccc3Oc2c1

InChI Key InChIKey=JZJOXLSYULKNLW-UHFFFAOYSA-N

Data  1 IC50  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50603132   

TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataIC50: 5.24E+3nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetEstrogen receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at estrogen receptor alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity in human GPBAR1 assessed as increase in intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at PPARalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetEstrogen receptor beta(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at estrogen receptor beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at PPARdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50603132(CHEMBL5171962)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed