BDBM50605255 CHEMBL5186557

SMILES CC(=O)Nc1cccc(Nc2nc(Nc3ccc(cn3)-c3ccsc3)ncc2Cl)c1

InChI Key InChIKey=CVEIEBFUSJRUSP-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50605255   

TargetDipeptidyl peptidase 1(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50605255(CHEMBL5186557)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant Cathepsin C using H-Gly-Arg-AMC as substrate pretreated for 30 mins followed by substrate addition and incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetDipeptidyl peptidase 1(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50605255(CHEMBL5186557)
Affinity DataIC50: 115nMAssay Description:Inhibition of Cathepsin C in human THP-1 cells using H-Gly-Phe-AFC as substrate pretreated for 1 hr followed by substrate addition and incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetDipeptidyl peptidase 1(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50605255(CHEMBL5186557)
Affinity DataIC50: 70nMAssay Description:Inhibition of Cathepsin C in human U-937 cells using H-Gly-Phe-AFC as substrate pretreated for 1 hr followed by substrate addition and incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProcathepsin L(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50605255(CHEMBL5186557)
Affinity DataIC50: 4.26E+3nMAssay Description:Inhibition of human recombinant Cathepsin L using Z-Leu-Arg-AMC as substrate pretreated for 60 mins followed by substrate addition and incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCathepsin B(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50605255(CHEMBL5186557)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant Cathepsin B using Z-Leu-Arg-AMC as substrate pretreated for 60 mins followed by substrate addition and incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCathepsin S(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50605255(CHEMBL5186557)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant Cathepsin S using MCA-Arg-Pro-Lys-Pro-Val-Glu-NVAL-Trp-Arg-Lys-(DNP)-NH2 as substrate pretreated for 60 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCathepsin K(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50605255(CHEMBL5186557)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human Cathepsin K using MCA-Arg-Pro-Lys-Pro-Val-Glu-NVAL-Trp-Arg-Lys-(DNP)-NH2 as substrate pretreated for 60 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed