BDBM50605538 CHEMBL5185314

SMILES [H][C@]12CN(CCN1c1ncnc3cc(c(Cl)c(OC2)c13)-c1c(C)ccc2[nH]ncc12)C(=O)C=C

InChI Key InChIKey=HRCJTOKNGFIMKE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50605538   

TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50605538(CHEMBL5185314)
Affinity DataIC50: 171nMAssay Description:Inhibition of C-terminal Avi and 6His-tagged human KRAS 2B G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50605538(CHEMBL5185314)
Affinity DataIC50: 171nMAssay Description:Inhibition of C-terminal Avi and 6His-tagged human KRAS 2B G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed