BDBM50606282 CHEMBL5204505::US20230287003, Example 12p

SMILES Cn1c2ccc(Nc3nc(ncc3Cl)N3CCC(F)(F)[C@@H](CO)C3)cc2c2N[C@@H](C3CC3)C(F)(F)COc2c1=O

InChI Key InChIKey=WAMJDHFDXROKDA-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50606282   

TargetB-cell lymphoma 6 protein(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM50606282(CHEMBL5204505 | US20230287003, Example 12p)
Affinity DataIC50: 4.57nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained 1 nM Trx-6×His-BCL6 (in house-produced, human BCL6 BTB domain c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent

TargetB-cell lymphoma 6 protein(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM50606282(CHEMBL5204505 | US20230287003, Example 12p)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of N-terminal thioredoxin-His6 tagged human BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI incubated for 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetB-cell lymphoma 6 protein(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM50606282(CHEMBL5204505 | US20230287003, Example 12p)
Affinity DataEC50:  2.70nMAssay Description:Degradation of BCL6 in human OCI-Ly1 cells incubated for 2 hrs by MSD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed