BDBM50607487 CHEMBL5220381

SMILES CC(c1c(cncc1Cl)Cl)Oc2cc(ncc2C#N)NC(=O)c3cn(c4c3nc(c(c4)Br)C=O)CCN5CCOCC5

InChI Key InChIKey=CGZXQBNAWSMHFF-UHFFFAOYSA-N

Data  8 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50607487   

TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50607487(CHEMBL5220381)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of FGFR4 V550L mutant (unknown origin) expressed in Escherichia coli Rosetta2 (DE3) (NEB) cells in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50607487(CHEMBL5220381)
Affinity DataIC50: 16nMAssay Description:Inhibition of N-terminal 6His-tagged FGFR4 (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 3A4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50607487(CHEMBL5220381)
Affinity DataIC50: 2.71E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam and testosterone as substrate in presence NADPH regenerating systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50607487(CHEMBL5220381)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50607487(CHEMBL5220381)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR2 (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50607487(CHEMBL5220381)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR3 (unknown origin) using Tyr04 peptide as substrate incubated for 1 hr in presence of ATP by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50607487(CHEMBL5220381)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate in presence NADPH regenerating systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50607487(CHEMBL5220381)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence NADPH regenerating systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed