BDBM50609702 CHEMBL5278476

SMILES [H][C@]12CN(c3cc(cc(c3)-c3cnc(N)c(OC(F)F)n3)C3CC3)[C@]([H])(CO1)C2

InChI Key InChIKey=PWQYILBUZALMLM-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50609702   

TargetMitogen-activated protein kinase kinase kinase 12(Human)
Denali Therapeutics

Curated by ChEMBL
LigandPNGBDBM50609702(CHEMBL5278476)
Affinity DataIC50: 47nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human DLK (9 to 111 residues) expressed in Sf21 cells assessed as reduction in substrate phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 13(Human)
Denali Therapeutics

Curated by ChEMBL
LigandPNGBDBM50609702(CHEMBL5278476)
Affinity DataIC50: 111nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human LZK (9 to 114 residues) expressed in Sf21 cells assessed as reduction in substrate phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Human)
Denali Therapeutics

Curated by ChEMBL
LigandPNGBDBM50609702(CHEMBL5278476)
Affinity DataEC50:  902nMAssay Description:Inhibition of human DLK expressed in HEK cells assessed as reduction in phospho-c-Jun level preincubated for 45 mins followed by doxycycline stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed