BDBM50609719 CHEMBL5283101

SMILES [H][C@]12CN(c3nc(cc(n3)-c3cnc(N)c(OC(F)F)n3)C3CC3)[C@]([H])(CN1C(=O)OCC)C2

InChI Key InChIKey=KBBJVNCJPHHXME-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50609719   

TargetMitogen-activated protein kinase kinase kinase 12(Human)
Denali Therapeutics

Curated by ChEMBL
LigandPNGBDBM50609719(CHEMBL5283101)
Affinity DataEC50:  45nMAssay Description:Inhibition of human DLK expressed in HEK cells assessed as reduction in phospho-c-Jun level preincubated for 45 mins followed by doxycycline stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Human)
Denali Therapeutics

Curated by ChEMBL
LigandPNGBDBM50609719(CHEMBL5283101)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human DLK (9 to 111 residues) expressed in Sf21 cells assessed as reduction in substrate phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 13(Human)
Denali Therapeutics

Curated by ChEMBL
LigandPNGBDBM50609719(CHEMBL5283101)
Affinity DataIC50: 45nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human LZK (9 to 114 residues) expressed in Sf21 cells assessed as reduction in substrate phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed