BDBM50611061 CHEMBL5291234

SMILES O=C(NCc1cn2cc(CNCC3CCCCC3)ccc2n1)c1cc(=O)n2ccccc2n1

InChI Key InChIKey=OBERVORNENYOLE-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50611061   

TargetN6-adenosine-methyltransferase catalytic subunit(Human)
Yunnan University

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataKd:  1.40nMAssay Description:Binding affinity to METTL3 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataKd:  1.40nMAssay Description:Binding affinity to METTL3/METTL14 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataKd:  1.40nMAssay Description:Binding affinity to full-length His-tagged METTL3/full length FLAG-tagged METTL14 (unknown origin) expressed in baculovirus expression system assesse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant METTL3/METTL14 (unknown origin) by RapidFire mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
Yunnan University

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataIC50: 17nMAssay Description:Inhibition of full length His-tagged METTL3 in baculovirus expression system (unknown origin) measured by mass spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
Yunnan University

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataIC50: 17nMAssay Description:Inhibition of full length His-tagged METTL3 (unknown origin) expressed in Sf9 cells by RapidFire mass spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataIC50: 17nMAssay Description:Inhibition of full length His-tagged METTL3 co-expressed with full length FLAG-tagged METTL14 (unknown origin) expressed in baculovirus expression sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
Yunnan University

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataIC50: 17nMAssay Description:Inhibition of METTL3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataIC50: 17nMAssay Description:Inhibition of full-length His-tagged METTL3/full length FLAG-tagged METTL14 (unknown origin) expressed in baculovirus expression system using synthet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataIC50: 17nMAssay Description:Inhibition of full length His-tagged human METTL3 co-expressed with full length FLAG-tagged human METTL14 expressed in baculovirus expression system ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
Yunnan University

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of human METTL3 expressed in HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
Yunnan University

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of METTL3 in human MOLM-13 cells assessed as down regulation of m6A RNA level incubated for 72 hrs by Dot blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetN(6)-adenosine-methyltransferase catalytic subunit METTL3(Mus musculus)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataIC50: 2.81E+3nMAssay Description:Inhibition of mouse METTL3More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed