BDBM50612179 CHEMBL5272567

SMILES CC(=O)N1CCC(CC1)n1cc(Nc2nc(OC3CCOCC3)c3nc(C)ccc3n2)cn1

InChI Key InChIKey=VMYCKCWYEIGQOV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50612179   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612179(CHEMBL5272567)
Affinity DataIC50: 3nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612179(CHEMBL5272567)
Affinity DataIC50: 71nMAssay Description:Inhibition of IRAK4 (unknown origin) phosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612179(CHEMBL5272567)
Affinity DataIC50: 30nMAssay Description:Inhibition of FLT3 (unknown origin) in presence of 600 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612179(CHEMBL5272567)
Affinity DataIC50: 20nMAssay Description:Inhibition of TRKA (unknown origin) in presence of 400 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed