BDBM50612604 CHEMBL5276202

SMILES Oc1cccc2ccc(C=CC3=CCN(Cc4ccccc4C(F)(F)F)CC3)nc12

InChI Key InChIKey=HCUMFCRMHUJZMD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50612604   

TargetAcetylcholinesterase(Electric eel)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50612604(CHEMBL5276202)
Affinity DataIC50: 110nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50612604(CHEMBL5276202)
Affinity DataIC50: 1.61E+5nMAssay Description:Inhibition of AChE in human SH-SY5Ycells assessed as reduction AChE activity using acetylthiocholine as substrate incubated for 24 hrs by DTNB based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50612604(CHEMBL5276202)
Affinity DataIC50: 1.66E+6nMAssay Description:Inhibition of AChE induced HFIP-pretreated amyloid beta (1 to 42 ) (unknown origin) aggregation incubated for 24 hr by Thioflavin T based fluorometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed