BDBM50616142 CHEMBL5428051

SMILES CCNC(=O)c1ccc2c([C@H]3CCN(CC4(O)CCCCC4)C[C@@H]3C)c(C)nn2c1

InChI Key InChIKey=MJLJMNMVTQVARE-UHFFFAOYSA-N

Data  2 KI  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50616142   

TargetProtein AF-9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50616142(CHEMBL5428051)
Affinity DataIC50: 2.98E+3nMAssay Description:Inhibition of N-terminal nanoLuc-tagged YEATS3 in HEK293T cells co-transfected with C-terminal halo-tagged histone 3.3 incubated for 24 hrs in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetYEATS domain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50616142(CHEMBL5428051)
Affinity DataIC50: 170nMAssay Description:Inhibition of N-terminal nanoLuc-tagged YEATS4 in HEK293T cells co-transfected with C-terminal halo-tagged histone 3.3 incubated for 24 hrs in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetYEATS domain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50616142(CHEMBL5428051)
Affinity DataKd:  340nMAssay Description:Binding affinity to C-terminal biotin-tagged YEATS4 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetYEATS domain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50616142(CHEMBL5428051)
Affinity DataKd:  53nMAssay Description:Binding affinity to YEATS4 (unknown origin) assessed as dissociation constant by isothermal calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetYEATS domain-containing protein 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50616142(CHEMBL5428051)
Affinity DataKi:  33nMAssay Description:Binding affinity to human his-tagged recombinant YEATS4 expressed in Escherichia coli assessed as inhibition constant using biotin tagged lysine 27-c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50616142(CHEMBL5428051)
Affinity DataKi:  4.64E+3nMAssay Description:Inhibition of hERG assessed as inhibition constant by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed