BDBM50617074 CHEMBL5417158

SMILES CCCn1c(NC(=O)c2cc(C)nn2CC)nc2cc(cc(OC3COC3)c12)C(N)=O

InChI Key InChIKey=JEHYKUKJJYNUCW-UHFFFAOYSA-N

Data  5 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50617074   

TargetStimulator of interferon genes protein(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50617074(CHEMBL5417158)
Affinity DataEC50:  280nMAssay Description:Agonist activity at human STING in human THP1-Blue ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50617074(CHEMBL5417158)
Affinity DataIC50: 5.60E+3nMAssay Description:Agonist activity at human 6His-tagged recombinant wild type STING CTD (139 to 37 residues) expressed in Escherichia coli BL21 (DE3) incubated for 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50617074(CHEMBL5417158)
Affinity DataIC50: 3.57E+3nMAssay Description:Agonist activity at human 6His-tagged recombinant STING R232H mutant CTD (139 to 37 residues) expressed in Escherichia coli BL21 (DE3) incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50617074(CHEMBL5417158)
Affinity DataIC50: 8.97E+3nMAssay Description:Agonist activity at human 6His-tagged recombinant STING G230A/R293Q double mutant CTD (139 to 37 residues) expressed in Escherichia coli BL21 (DE3) i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50617074(CHEMBL5417158)
Affinity DataIC50: 8.40E+3nMAssay Description:Agonist activity at human 6His-tagged recombinant STING R293Q mutant CTD (139 to 37 residues) expressed in Escherichia coli BL21 (DE3) incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Mouse)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50617074(CHEMBL5417158)
Affinity DataIC50: 4.35E+3nMAssay Description:Agonist activity at mouse 6His-tagged recombinant STING CTD (144 to 378 residues) expressed in Escherichia coli BL21 (DE3) incubated for 10 mins by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Mouse)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50617074(CHEMBL5417158)
Affinity DataEC50:  5.22E+3nMAssay Description:Agonist activity at mouse STING in mouse RAW-Lucia ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50617074(CHEMBL5417158)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human STING in STING knockout human THP1-Blue ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Mouse)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50617074(CHEMBL5417158)
Affinity DataEC50: >2.00E+5nMAssay Description:Agonist activity at mouse STING in STING knockout mouse RAW-Lucia ISG cells incubated for 24 hrs in presence of PMA by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed